ClinicalChemistry Blog Notes 23D: Toxicology

NOW THAT WE ARE ALL TOXIC --- DETOX IS THE KEY

http://www.pharmtox.utoronto.ca/programs/cpbt.htm

Let’s face it, people nowadays die not because of old age, but because of certain degenerative diseases or in a more simple term --- the lifestyle diseases. This should not shock anyone. We are struggling to survive in our incredibly polluted environment.

http://noelortega17.blogspot.com/2012/03/drug-abuse-prevention-and-control-week.html

In these days, it is quite impossible to avoid toxins, radiations, stress, smokes and other chemicals that damage our body and reduce its vitality. These stressors have probably been here since the very beginning of man-kind. Science is continuously innovating, that then introduced toxicology to all the people in different places.

Toxicology is the study of the adverse effects of chemicals on living organisms. The irresistible advancement of these studies let the people be aware of anything that have a potential risk. It then provides us management and prevention aiding us out in longevity of our lives.

http://www.topsecretwriters.com/2011/06/pharmaceutical-companies-are-turning-americans-into-drug-addicts/

What we did in our past life will manifest in the future. Instances like unhealthy diet because those who were fund of eating fries, burgers, pizzas, junk foods which contain higher level of salts than the recommended amount are related to cardiovascular risks, also, consumption of saturated fats and trans fatty acids may be linked to heart diseases.

http://www.dawnmwilliams.com/alcohol.html

There is also the harmful use of alcohol. We are aware that there is an increasing mortality rate from cancer, cardiovascular diseases and liver cirrhosis. Another is tobacco smoking or any other pollution and harmful airborne substances that in turn increase respiratory ailments. Alcohol and cigarette/tobacco smoking are the most substance abuse now a days.

http://en.wikipedia.org/wiki/Tobacco_smoking

Likewise, insufficient physical activities or the so-called sedentary lifestyle could greatly contribute to a number of health issues like obesity, diabetes, heart diseases and worst being disabled due to stroke.

http://www.insidecostarica.com/dailynews/2012/march/26/costarica12032606.htm

However, most times lifestyle diseases do refer to those conditions that could be prevented if behavior was changed. There are various indications to recommend that diseases have decreased when enough studies occur.

http://www.youtube.com/watch?feature=player_embedded&v=0JZPNmkV3zE

We need detoxification as more often as possible. Lifestyle diseases seems like they're part of human existence. They're unavoidable; it is like every now and then I perceived something new we consume or do is causing an illness. All substances are toxic under the right conditions, as it has been considered. We avoid one unhealthy habit only to move to another that later will manifest to a disease.

http://mynaturopath.webs.com/metabolicdetoxification.htm

Metabolic detoxification is a complex process involving a chain of chemical reactions that occur primarly within the liver and kidneys:

Phase I (Functionalization): Enzymes secreted by the liver break down toxins into modified, highly reactive molecules. (Ironically, a by product of functionalization is the creation of free radicals, molecules that can wreak cellular damage if not quickly neutralized.)

Phase II (Conjugation): Chemicals such as the amino acid gluthathione produced by the liver bind with the modified toxins, neutralizing them and making them more water soluble.

Transport: Proteins deliver the neutralized toxins to the kidneys, where they are excreted via urine; or the gastrointestinal tract, where they are excreted via stool.

Optimal metabolic detoxification helps the body cleanse itself of harmful substances before they can accumulate in tissue and affect health. But factors such as toxic overload, genetic predisposition, and insufficient levels of keys nutrients can impair this process, increasing a person's susceptibility to toxicity-related diseases.

BRANCHES OF TOXICOLOGY SCIENCES

Clinical Toxicology: (Hospital Setting)

Deal with emergencies such as overdoses, poisonings, attempted siucides
Compound identification and qualification
Sign and Symptom management
Emergency care--home poisoning
Poison control

http://www.toxicology-consulting.com/

Forensic Toxicology: (Medical Examiner's Office)

Medical-legal aspects of poisonings
Identification and quantification of poisons
Establish relationship between tissue residual level and probable cause of death